Quadruplex nucleic acids are promising targets for cancer therapy. In this study we used a fragment‐based approach to create new flexible G‐quadruplex (G4) DNA‐interactive small molecules with good calculated oral drug‐like properties, based on quinoline and triazole heterocycles. G4 melting… Read more ›
![Indolo[3,2-c]quinoline Binders to Human Telomeric G-Quadruplex](https://i1.wp.com/chemistrybits.com/wp-content/uploads/2015/03/lavrado.png?fit=220%2C186)
A library of 5-methylindolo[3,2-c]quinolones (IQc) with various substitution patterns of alkyldiamine side chains were evaluated for G-quadruplex (G4) binding mode and efficiency. Fluorescence resonance energy transfer melting assays showed that IQcs with a positive charge in the heteroaromatic nucleus and… Read more ›
![Effect of Indolo[3,2-b]quinolines on Cancer Cells](https://i2.wp.com/chemistrybits.com/wp-content/uploads/2013/08/nfig004.gif?fit=220%2C198)
G-quadruplex (G4) DNA structures in telomeres and oncogenic promoter regions are potential targets for cancer therapy, and G4 ligands have been shown to modulate telomerase activity and oncogene transcription. Herein we report the synthesis and G4 thermal stabilisation effects, determined… Read more ›