- June 2019
- November 2018
- September 2018
- March 2018
- January 2018
- November 2017
- May 2017
- August 2016
- April 2016
- August 2015
- July 2015
- June 2015
- April 2015
- March 2015
- January 2015
- April 2014
- September 2013
- August 2013
- July 2013
- June 2013
- January 2013
- May 2012
- March 2012
- November 2011
- May 2011
- April 2011
- February 2011
- January 2011
- September 2010
- November 2009
- July 2009
- March 2009
- November 2008
- September 2008
- January 2008
- December 2007
- October 2007
- October 2006
- November 2004
- February 2003
- November 2002
- April 1999
Combining 1,3‐Ditriazolylbenzene and Quinoline to Discover a New G‐Quadruplex‐Interactive Small Molecule Active against Cancer Stem‐Like Cells
Quadruplex nucleic acids are promising targets for cancer therapy. In this study we used a fragment‐based approach to create new flexible G‐quadruplex (G4) DNA‐interactive small molecules with good calculated oral drug‐like properties, based on quinoline and triazole heterocycles. G4 melting… Read more ›