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Insights on P-Glycoprotein’s Efflux Mechanism Obtained by Molecular Dynamics Simulations

P-Glycoprotein (P-gp) is often involved in multidrug resistance (MDR) to the pharmacological action of a wide number of anticancer agents. In this article, a series of molecular dynamics simulations of murine’s P-gp were developed, elucidating the importance of the lipid Read more ›