Monthly Archives: March 2015

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Indolo[3,2-c]quinoline G-Quadruplex Stabilizers: a Structural Analysis of Binding to the Human Telomeric G-Quadruplex

Indolo[3,2-c]quinoline Binders to Human Telomeric G-Quadruplex

A library of 5-methylindolo[3,2-c]quinolones (IQc) with various substitution patterns of alkyldiamine side chains were evaluated for G-quadruplex (G4) binding mode and efficiency. Fluorescence resonance energy transfer melting assays showed that IQcs with a positive charge in the heteroaromatic nucleus and… Read more ›

Daniel J.V.A. dos Santos
Cancer, G-quadruplex
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A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins

Tryptophanol-derived oxazolopiperidone lactam inhibitis P53-MDM2 interaction

Inactivation of the p53 tumor suppressor protein by interaction with murine double minute (MDM) proteins, MDM2 and MDMX, is a common event in human tumors expressing wild-type p53. In these tumors, the simultaneous inhibition of these interactions with MDMs, for… Read more ›

Daniel J.V.A. dos Santos
Cancer, MDM2-P53
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