January 2015 • Computer Modeling

Reversing cancer multidrug resistance: insights into the efflux by ABC transports from in silico studies

One of the greatest threats to cancer treatment is the development, by some tumors, of resistance to the pharmacological action of several structurally unrelated cytotoxic agents—multidrug resistance (MDR). As P-glycoprotein (P-gp) is one of the most studied ATP-dependent efflux pumps… Read more ›

Jan 18, 2015

Daniel J.V.A. dos Santos

ABC transporters, Cancer, Multidrug resistance, P-gp/ABCB1, Publication review

ABC transporters, ABCB1, Docking, Efflux Mechanism, Efflux Modulation Mechanisms, MDR, Molecular dynamics, Multidrug resistance, P-Glycoprotein, Pharmacophore, QSAR, Review, Substrate-Binding Sites

Oxazoloisoindolinones with in vitro antitumor activity selectively activate a p53-pathway through potential inhibition of the p53–MDM2 interaction

Oxazoloisoindolinones inhibit p53–MDM2 interaction

One of the most appealing targets for anticancer treatment is the p53 tumor suppressor protein. In half of human cancers, this protein is inactivated due to endogenous negative regulators such as MDM2. Actually, restoring the p53 activity, particularly through the… Read more ›

Jan 13, 2015

Daniel J.V.A. dos Santos

Cancer, MDM2-P53

Colon Adenocarcinoma, MDM2, Oxazoloisoindolinones, oxazolopyrrolidone lactams, P53, Tumor suppressor

Computer Modeling

Daniel J.V.A. dos Santos and coworkers

Monthly Archives: January 2015

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Reversing cancer multidrug resistance: insights into the efflux by ABC transports from in silico studies

Oxazoloisoindolinones with in vitro antitumor activity selectively activate a p53-pathway through potential inhibition of the p53–MDM2 interaction