MDMX Archives • Computer Modeling

Welcoming Daniela Peixoto to the group

Dr. Daniela Peixoto was hired to work on the project entitled Drug Discovery for p53 PPI-targets. This project is financed by the Portuguese Science Foundation (FCT) to discover and develop novel molecules able of inhibiting the p53–MDM2/X interaction. The computational… Read more ›

Dec 03, 2018

Daniel J.V.A. dos Santos

Daniela Peixoto, FCT, MDM2, MDMX, Molecular docking, P53, Pharmacophore, Virtual screening

A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins

Tryptophanol-derived oxazolopiperidone lactam inhibitis P53-MDM2 interaction

Inactivation of the p53 tumor suppressor protein by interaction with murine double minute (MDM) proteins, MDM2 and MDMX, is a common event in human tumors expressing wild-type p53. In these tumors, the simultaneous inhibition of these interactions with MDMs, for… Read more ›

Mar 23, 2015

Daniel J.V.A. dos Santos

Cancer, MDM2-P53

MDM2, MDMX, Oxazolopiperidone lactam, P53, Tryptophanol

Computer Modeling

Daniel J.V.A. dos Santos and coworkers

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Welcoming Daniela Peixoto to the group

A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins