Monthly Archives: June 2013

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Exploring the Molecular Basis of Qo bc1 Complex Inhibitors Activity to Find Novel Antimalarials Hits

Qo bc1 Complex Inhibitors

Cytochrome bc1 complex is a crucial element in the mitochondrial respiratory chain, being indispensable for the survival of several species of Plasmodia that cause malaria and, Qo bc1 Complex Inhibitorstherefore, it is a promising target for antimalarial drug development. We… Read more ›

Daniel J.V.A. dos Santos
Malaria
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Assessing the Stabilization of P-Glycoprotein’s Nucleotide- Binding Domains by the Linker, Using Molecular Dynamics

Stabilization of P-Glycoprotein’s Nucleotide-Binding Domains by the Linker

This paper focuses on the importance of the intermediate linker sequence for the stabilization of the cytoplasmic portion of murine P-glycoprotein, an ABC transporter involved in Multidrug Resistance (MDR) in cancer. Three putative protein-protein interaction areas were predicted to exist,… Read more ›

Daniel J.V.A. dos Santos
Cancer, Multidrug resistance, P-gp/ABCB1
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